SMT uses a unique bonding scheme to manufacture very high ligand density silica-based Anion and Cation SMT ionRes IC columns for separation of oxyhalides and general inorganic ions.
Separation Methods Technologies Inc.

C18 Columns

SMT manufactures Symplex C18 columns for a wide variety of applications including environmental, pharmaceuticals, steroids, fatty acids, phthalates, and more
  • Proprietary bonding scheme that allows the resulting bonded phases to perform reliably
  • Made with spherical silica with ultra-high surface area
  • Extremely sensitive and exceptional performance
Separation Methods Technologies Inc.

C18 Columns

  • Ultra-high surface area for higher sensitivity than our OD Series
  • Utilizes advanced Self-Assembled Monolayers (SAM) to achieve bonded phase coverages that approach 100%
  • Extremely high silanol site coverage
  • Wide range of pH stability (1 to 12)

Separation Methods Technologies Inc.

HILIC Columns | RP Columns

SMT manufactures bioSAM LC columns for analysis of proteins, peptides and other biomolecules

Separation Methods Technologies Inc.


For the separation of many biomolecules such as proteins, nucleotides, oligonucleotides, polynucleotides, high molecular weight RNAs and plasmid DNAs
SMT DEAE [Di-Ethyl-Amino-Ethyl] column provides a unique chemically attached hydrophilic and weak anion exchange type

Bulk Packings



Providing Separation Alternatives Since 1993
Separation Methods Technologies, Incorporated (SMT) is a surface chemistry research and manufacturing corporation founded in 1993. SMT’s goal is to provide chromatographers with outstanding specialty HPLC columns and bulk packing materials for various separation chemistries, ranging from analytical to the process scale. The primary focus for SMT is on the creation of well-organized functional molecules on substrate surfaces for various functions, including chromatographic applications and materials engineering.


Chromatography for Industrial Applications

News & Updates

News & Updates




Our Large Clients Include:

SMT Does Business with


We are Original Equipment Manufacturer (OEM), and as such, have a complete control over quality and ensuring reproducibility of your chromatography. As an OEM, we utilize proven procedures at every stage of manufacture to guarantee consistency in our silica purity, pore size, particle size, as well as chemical bonding.
SMT’s policy has been to never change any product that has an existing customer base; however, when improvements are made, an entirely new SMT product line is introduced. In addition, SMT HPLC columns are equipped with standard 1/16″ fittings and are compatible with ALL standard HPLC/UHPLC systems (including systems by Agilent, Waters, ThermoFisher, Shimadzu, etc.)
Worldwide Capability
SMT has a worldwide distribution network with products available all over United States, Canada, France, Germany, England, Asia, Africa and other locations. SMT delivers the same high quality products throughout the world.