Informed-Proteomics: open-source software package for top-down proteomics — SMT REFERENCED ARTICLE

Jungkap Park, Paul D Piehowski, Christopher Wilkins, Mowei Zhou, Joshua Mendoza, Grant M Fujimoto, Bryson C Gibbons, Jared B Shaw, Yufeng Shen, Anil K Shukla, Ronald J Moore, Tao Liu, Vladislav A Petyuk, Nikola Tolić, Ljiljana Paša-Tolić, Richard D Smith, Samuel H Payne & Sangtae Kim
Nature Methods, Volume 14

Nature Methods, Volume 14 Separation Methods TechnologiesTop-down proteomics, the analysis of intact proteins in their endogenous form, preserves valuable information about post-translation modifications, isoforms and proteolytic processing. The quality of top-down liquid chromatography–tandem MSMS (LCLC-MSMS/MSMS) data sets is rapidly increasing on account of advances in instrumentation and sample-processing protocols. However, top-down mass spectra are substantially more complex than conventional bottom-up data…The analytical column was prepared in house by slurry packing 3 μm diameter C2 [BMEB C2] stationary phase (Separation Methods Technology, Newark, Delaware) into a 50 cm length of 360 μm o.d. × 100 μm i.d. fused silica capillary column…READ MORE HERE


SMT PAH 1 Column

Polycyclic aromatic hydrocarbons (PAHs, also polyaromatic hydrocarbons or polynuclear aromatic hydrocarbons) are large organic compounds produced during combustion. Many of these compounds are carcinogenic and are often found in water, air and other natural habitats. Monitoring of these compounds is very crucial for a healthy environment.
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SMT CIB Teicoplanin Column

SMT manufactures the most reliable silica based Chemically Immobilized Biomolecules columns for both normal and reversed phase separation available in the market. SMT CIB-TE column is made through bonding of the antibiotic, Teicoplanin with 1,6-Diisocyanatohexane, using “Total Coverage” technology, both patented and proprietary. This covalently bonded Teicoplanin column is extremely useful for performing a wide variety of chiral separations with amino acids, carboxylic acids and neutral compounds.


SMT UHPLC Glass-Lined Steel Columns


For Extremely High Performance Efficiency

  • Inert and exhibits excellent resistance to the harshest of conditions
  • Biocompatible making it ideal for many applications
  • Maximum temperature for continuous use at 500°C
  • Excellent resistance to strong acids and bases
  • Available for most bonded phases
  • 20Apr/16

    LCGC | New Chromatography Columns and Accessories for 2016: April 2016

    LCGCSeparation Methods Technologies introduced an FPP version of a C30 chemistry… Separation Methods Technologies launched a protein A column based on FPP substrate. According to the company, a proprietary bonding strategy using self-assembled monolayers (SAMs) ensures complete removal of nonspecific binding sites. Protein A has been shown to provide high binding capacity for mammalian IgG…

    By: Dave Bell
    Original Article